Acknowledgements Dr. Beyond weight loss: A review of the therapeutic uses of very-low-carbohydrate ketogenic diets. WY conceived, designed, and coordinated the study; participated in data collection; performed statistical analysis; and drafted the manuscript. Moreover, in obese children it has been found that, in the early phase of obesity, alleles of the insulin gene variable number of tandem repeat VNTR locus are associated with different effects of body fatness on insulin secretion [ 27 ]. In addition, on the day the diet was initiated, diabetes medications were reduced — generally, insulin doses were halved, and sulfonylurea doses were halved or discontinued. Week 16 Mean SD. Davies M.
The low-carbohydrate, ketogenic diet LCKD may be effective for improving glycemia and reducing medications in patients with type 2 diabetes. From an outpatient clinic, we recruited 28 overweight participants with type 2 diabetes for a week single-arm pilot diet intervention trial. Participants returned every other week for measurements, counseling, and further medication adjustment. The primary outcome was hemoglobin A 1c. Twenty-one of the 28 participants who were enrolled completed the study. Twenty participants were men; 13 were White, 8 were African-American. Diabetes medications were discontinued in 7 participants, reduced in 10 participants, and unchanged in 4 participants. The mean body weight decreased by 6. In linear regression analyses, weight change at 16 weeks did not predict change in hemoglobin A 1c.
Week 2 Mean SD. Tay J.