Am J Hum Genet — Diet composition has far-reaching effects on mammalian physiology [ 40 ]. You are viewing this page in draft mode. Genome Med Intake of a high-fat diet was associated with hepatic accumulation of fatty acids, which can affect cell energy metabolism and signaling to stimulate carcinogenesis. In some cases the absence of TSP1 may cause elevation of an amino acid by blocking its catabolism.
Brain — In summary, our data indicate that inhibition of SCHAD reduces the body weight according to the excretion of acylcarnitines, which associates with a reduced fuel efficiency. The volcano plot was generated as a log scaled axes of fold change Log2, x-axis and p value -log10, y-axis. Cancer Sc ; 98 : 6— We thank Roger Low for contributions at early project stages and Keng Hwee Neo for exploratory work and controls not included here. By positional cloning, we recently identified Tbc1d1 in the obesity QTL Nob1 that reduces fatty acid oxidation in muscle, thereby enhancing obesity and diabetes susceptibility Cyclooxygenase-2 cox-2 blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung.
Various metabolites are generated solely in the presence of the gut microflora, enter the blood flow, and possibly accumulate in kidney. Half E, Arber N. Chen YM et al Associations of gut-flora-dependent metabolite trimethylamine- N -oxide, betaine and choline with non-alcoholic fatty liver disease in adults. Despite that most amino acids are directly absorbed in the small intestine and further metabolized by the host [ 44, 45 ], the majority including tryptophan are degraded by the microbiota residing the large intestine [ 17, 46 ]. References 1. Annu Rev Genet — Yamada Y, Mori H. Interestingly, it has been shown that a substantial amount of the dietary tryptophan in the human gut is metabolized by bacteria [ 17 ].